| Product Name |
Dopamine Hydrochloride |
| Other Name |
3-Hydroxytyramine Hydrochloride/Dopamine HCL |
| CAS No. |
62-31-7 |
| Molecular Formula |
C8H12ClNO2 |
| Molecular Weight |
189.64 |
| Appearance |
White Powder |
| Assay |
98% |
| Grade |
Pharmaceutical Grade |
| Brand |
Greenway |
Product Introduction:
Dopamine, a sympathomimetic amine vasopressor, is the naturally occurring immediate precursor of norepinephrine. Dopamine hydrochloride is a white to off-white crystalline powder, which may have a slight odor of hydrochloric acid. It is freely soluble in water and soluble in alcohol. Dopamine HCl is sensitive to alkalies, iron salts, and oxidizing agents. Chemically it is designated as 4-(2-aminoethyl) pyrocatechol hydrochloride, and the structural formula is:
Dopamine Hydrochloride Injection is a clear, practically colorless, sterile, pyrogen-free, aqueous solution of dopamine HCl for intravenous infusion after dilution. Each mL contains either 40 mg, 80 mg, or 160 mg of dopamine hydrochloride (equivalent to 32.3 mg, 64.6 mg and 129.2 mg of dopamine base respectively) in water for injection, q.s. Each mL of all preparations contains the following: sodium metabisulfite 9 mg added as an antioxidant; citric acid, anhydrous 10 mg and sodium citrate, dihydrate 5 mg added as a buffer. The pH range (2.5 to 5.0) may be adjusted with additional citric acid and/or sodium citrate.
Dopamine must be diluted in an appropriate sterile parenteral solution.
Indications:
Dopamine HCl is indicated for the correction of hemodynamic imbalances present in the shock syndrome due to myocardial infarction, trauma, endotoxic septicemia, open-heart surgery, renal failure, and chronic cardiac decompensation as in congestive failure.
Patients most likely to respond adequately to dodpamine HCl are those in whom physiological parameters, such as urine flow, myocardial function, and blood pressure, have not undergone profound deterioration. Multiclinic trials indicate that the shorter the time interval between onset of signs and symptoms and initiation of therapy with volume correction and dopamine HCl, the better the prognosis. Where appropriate, blood volume restoration with a suitable plasma expander or whole blood should be accomplished or completed prior to administration of dopamine HCl.
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