Nootropics Raw Powder CAS 148372-04-7 Gts-21/Dmxb-a

• Customization: Available
• Powder: Yes
• Customized: Customized
• Certification: ISO
• Suitable for: Adult
• State: Powder
• Purity: >99%
• CAS No.: 156223-05-1
• Other Names: Nefiracetam
• Mf: C19h22cl2n2o2
• Grade: Pharmaceutical Grade
• Shelf Life: 2 Years
• Type: Antibiotic and Antimicrobial Agents
• Transport Package: Paper Bag or Drum
• Specification: 1kg/bag; 25kg/drum
• Trademark: Greenway Biotech
• Origin: China
• HS Code: 2942000000
• Production Capacity: 50kg/Year

Product Description

99% Purity Nootropic Nutrition Supplements CAS 156223-05-1 Bulk DMXB-A /
GTS-21 Powder 

Product Name	DMXB-A / GTS-21 Powder
Brand Name	Greenway Biotech
Purity	99%
CAS No.	156223-05-1
Appearance	White Powder
Test Method	HPLC

Description:

    GTS-21 (also known as DMBX-A), is a novel, small-molecule, orally active and selective
alpha-7 nicotinic acetylcholine (nACh) receptor agonist that has demonstrated memory and
cognition enhancement activity in human clinical trials. Athenagen licensed the exclusive
rights to the compound and a related library of analogs as part of the acquisition of Osprey
Pharmaceutical Company in April 2006. GTS-21 has been studied in multiple Phase I studies
in healthy volunteers and one Phase I/II study in schizophrenic patients. In all studies, the
compound was well tolerated. In a Phase I multi-dose, double-blind, placebo controlled study
in healthy adults, GTS-21 also demonstrated cognitive enhancement across all doses, with a
statistically significant improvement in attention related and memory related tasks.

    GTS-21 was O-demethylated to yield compounds that were then subject to glucuronidation.
Three of the metabolites in rat urine were isolated and characterized as 4-OH-GTS-21,
4-OH-GTS-21 glucuronide and 2-OH-GTS-21 glucuronide. The major urinary metabolites
were 4-OH-GTS-21 glucuronide and 2-OH-GTS-21 glucuronide. In vitro chemical inhibition
of cytochrome P450 in human liver microsomes indicated that CYPIA2 and CYP2E1 were the
isoforms primarily responsible for the O-demethylation of GTS-21, with some contribution from
CYP3A.






Application&Function:

     DMBX-anabaseine (DMBX-A) is a derivative of the natural product anabaseine that acts as a
partial agonist at neural nicotinic acetylcholine receptors. It binds to both the α4β2 and α7
subtypes, but activates only the α7 to any significant extent.