| Customization: | Available |
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| CAS No.: | - |
| Formula: | - |
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| Product Name | Retinoic Acid |
| Other Names | Vitamin A Acid/Tretinion/Tretinoin |
| CAS No. | 302-79-4 |
| Molecular Formula | C20H28O2 |
| Molecular Weight | 300.44 |
| Appearance | Yellow Powder |
| Assay | 99% |
| Grade | Cosmetic&Pharmaceutical Grade |
| Brand Name | Greenway |
Tretinoin is the acid form of vitamin A and is also known as all-trans retinoic acid or ATRA. It is a drug commonly used to treat acne vulgaris and keratosis pilaris. It is available as a cream or gel It is also used to treat acute promyelocytic leukemia. It is also available as a generic.
Its success in treating acute promyelocytic leukemia was a major breakthrough in the treatment of this type of leukemia.It works in APL because the majority of cases involve a chromosomal translocation of chromosomes 15 and 17, which causes genetic fusion of the retinoic acid receptor gene to the promyelocytic leukemia gene.
This fusion PML-RAR protein is responsible for preventing immature myeloid cells from differentiating into more mature cells. This block in differentiation is thought to cause leukemia.
ATRA acts on PML-RAR to lift this block, causing the immature promyelocytes to differentiate to normal mature blood cells thus decreasing promyelocytes.
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