Pharmaceutical Ingredient API Medicine Grade Antihypertensive Drugs Raw Materials CAS 137862-53-4 Pure 99% Valsartan Powder

• Powder: Yes
• Customized: Non-Customized
• Certification: Coa, MSDS
• Suitable for: Other
• State: Powder
• Purity: >99%
• Model NO.: VAL
• Transport Package: 1kg/Bag, 25kg/Drum
• Specification: 99%
• Trademark: Greenway
• Origin: Jiangsu, China
• HS Code: 2942000000
• Production Capacity: 500 Kilograms/Month

Product Description

Pharmaceutical Ingredient API Medicine Grade Antihypertensive Drugs Raw Materials CAS 137862-53-4 Pure 99% Valsartan Powder

Product Description of Pharmaceutical Ingredient API Medicine Grade Antihypertensive Drugs Raw Materials CAS 137862-53-4 Pure 99% Valsartan Powder

{Product Name}:	Valsartan
{Other Name}:	N/A
{Test Method.}:	HPLC
{Appearence.}:	White Powder
{Specification}:	99%
{MOQ}:	1kg

Valsartan is used clinical for receptor antagonist of angiotensin AT1, has good effect to the different degree of hypertension patients who used other antihypertensive without efficacy , is a new generation of highly efficient antihypertensive .

Valsartan belongs to the angiotensin II receptor blocker (ARB) family of drugs, which also includes telmisartan, candesartan, losartan, olmesartan, and irbesartan. ARBs selectively bind to angiotensin receptor (AT1) and prevent the protein angiotensin II from binding and exerting its hypertensive effects, which include vasoconstriction, stimulation and synthesis of aldosterone and ADH, cardiac stimulation, and renal reabsorption of sodium, among others. Overall, valsartan's physiologic effects lead to reduced blood pressure, lower aldosterone levels, reduced cardiac activity, and increased excretion of sodium.

Valsartan also affects the renin-angiotensin aldosterone system (RAAS), which plays an important role in hemostasis and regulation of kidney, vascular, and cardiac functions. Pharmacological blockade of RAAS via AT1 receptor blockade inhibits negative regulatory feedback within RAAS, which is a contributing factor to the pathogenesis and progression of cardiovascular disease, heart failure, and renal disease. In particular, heart failure is associated with chronic activation of RAAS, leading to inappropriate fluid retention, vasoconstriction, and ultimately a further decline in left ventricular function. ARBs have been shown to have a protective effect on the heart by improving cardiac function, reducing afterload, increasing cardiac output and preventing ventricular hypertrophy and remodelling.

Function of Pharmaceutical Ingredient API Medicine Grade Antihypertensive Drugs Raw Materials CAS 137862-53-4 Pure 99% Valsartan Powder
Valsartan is an angiotensin II receptor antagonistwith particularly high affinity for the type I (AT1) angiotensin receptor. By blocking the action of angiotensin, valsartan dilates blood vessels and reduces blood pressure. In the U.S., valsartan is indicated for treatment of high blood pressure, congestive heart failure (CHF), or post-myocardial infarction (MI) . 

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