Factory Supply Pharmaceutical Intermediate Terbinafine HCl Raw Powder CAS 78628-80-5 High Purity Terbinafine Hydrochloride with Low Price

• Powder: Yes
• Customized: Customized
• Certification: ISO 9001
• Suitable for: Adult
• State: Solid
• Purity: >99%
• Mf: C21h26cln
• Appearance: White Powder
• MOQ: 1kg
• Grade: Pharmaceutical Grade
• Test Method: HPLC
• Mesh: 100% Pass 80 Mesh
• OEM Service: Accept
• MSDS: Available
• Shelf Life: 2 Years
• CAS Number: 78628-80-5
• Einecs: 616-640-4
• Molecular Weight: 327.89
• Transport Package: Paper Bag or Drum
• Specification: 1kg/bag; 25kg/drum
• Trademark: Greenway Biotech
• Origin: China
• HS Code: 2942000000
• Production Capacity: 1000kg/Year

Product Description

Factory Supply Pharmaceutical Intermediate Terbinafine HCl Raw Powder CAS
78628-80-5 High Purity Terbinafine Hydrochloride with Low Price

Product Name	Terbinafine Hydrochloride
Brand Name	Greenway Biotech
Purity	99%
MF	C21H26ClN
Appearance	White Powder
Test Method	HPLC

Terbinafine hydrochloride is an antifungal, which is highly hydrophobic and tends to accumulate
in hair, skin, nails, and fatty tissue.

Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol
and dichloromethane, soluble in ethanol, and slightly soluble in water.

Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase,
an enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine
prevents conversion of squalene to lanosterol, ergosterol cannot be synthesize




Function:

Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol
and dichloromethane, soluble in ethanol, and slightly soluble in water. Like other allylamines,
terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme that is
part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion
of squalene to lanosterol, ergosterol cannot be synthesized. This is thought to change cell
membrane permeability, causing fungal cell lysis.

Application:

1. Terbinafine is mainly effective on the dermatophyte group of fungi.

2. As a 1% cream or powder, it is used topically for superficial skin infections such as jock
itch (tinea cruris), athlete's foot (tinea pedis), and other types of ringworm (tinea corporis).
Terbinafine cream works in about half the time required by other antifungals.

3. Oral 250mg tablets are often prescribed for the treatment of onychomycosis, a fungal nail
infection, typically by a dermatophyte or Candida species. Fungal nail infections are located
deep under the nail in the cuticle to which topically applied treatments are unable to penetrate
in sufficient amounts. The tablets may, rarely, cause hepatotoxicity, so patients are warned of
this and may be monitored with liver function tests. Alternatives to oral administration have
been studied. 

4. Terbinafine may induce or exacerbate subacute cutaneous lupus erythematosus. Persons
with lupus erythematosus should first discuss possible risks with their doctor before initiation
of therapy.